Lyve1 Rabbit Polyclonal Antibody

SKU DP3513

Lyve1 rabbit polyclonal antibody, Purified

Product Data

• Application: ELISA, FC, IF, IHC, WB
• Recommended Dilution: ELISA (1-15 µg/ml).; Western blot (1-5 µg/ml).; FACS analysis (3-10 µg/ml). ; Immunofluorescence.; Immunohistochemistry on Frozen Sections (1-5 µg/ml). ; For formalin-fixed, paraffin-embedded sections use the immunogen affinity purified antibody Cat.-No DP3513P.
• Reactivity: Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Highly pure recombinant Mouse soluble LYVE-1 (Ala24-Gly228) produced in insect cells (Cat.-No DA3524).; This recombinant soluble LYVE-1 consists of amino acid 24 (Ala) to 228 (Gly) and is fused to a C-terminal His-tag (6xHis).
• Specificity: This antibody detetcs Mouse and Rat Lyve-1. ; This antibody is not reactive with Human LYVE-1.
• Buffer: PBS, pH 7.2 without preservatives or stabilizers; State: Purified; State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
• Purification: Protein G Chromatography (+his tag depletetion)
• Conjugation: Unconjugated
• Storage: The lyophilized IgG is stable at 2-8°C for one month and at -20°C for longer. ; When reconstituted the antibody is stable for at least six weeks at 2-8°C. ; For longer store in aliquots at -20°C. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Ambient
• Gene Name: lymphatic vessel endothelial hyaluronan receptor 1
• Database Link:
  Q8BHC0
• Background: LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212- esidue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE- molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymphspecific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
• Synonyms: LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1

Reference Data