PROX1 (C-term) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | Suitable for Western Blot and Immunohistochemistry on Frozen and Paraffin Sections. |
| Reactivity | Fish, Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide corresponding to the Homeobox domain of Prox1. |
| Specificity | This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells. |
| Buffer | State: Purified State: Liquid purified IgG fraction in PBS |
| Concentration | lot specific |
| Conjugation | Unconjugated |
| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | prospero homeobox 1 |
| Database Link | |
| Background | The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94% similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells. |
| Synonyms | PROX1 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
| Protein Families | Embryonic stem cells, ES Cell Differentiation/IPS |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
VEGF-A/HGF induce Prox-1 expression in the chick embryo chorioallantoic membrane lymphatic vasculature
Cimpean, Seclaman, Ceauşu et al
Clin Exp Med (2010) 10 (3), 169-72 DOI: 10.1007/s10238-009-0085-6
Cimpean, Seclaman, Ceauşu et al
Clin Exp Med (2010) 10 (3), 169-72 DOI: 10.1007/s10238-009-0085-6
Cited by 22
AI Summary: OriGene’s pBlast VEGF-A and pBlast HGF plasmids were used to deliver VEGF-A and HGF in combination, enabling the authors to investigate and demonstrate their role in inducing Prox-1 expression and promoting lymphatic and blood vessel formation in the chick embryo chorioallantoic membrane.
Showing 1-1 of 1 papers.
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