PROX1 (C-term) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | Western blotting (1/1,000). Immunohistochemistry on Frozen and Paraffin Embedded Sections (1/500-1/1,000). Requires high temperature antigen unmasking for paraffin sections: citrate pH 6.0 at 100°C for 10 min. |
| Reactivity | Human, Mouse, Rat, Zebrafish |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Peptide corresponding to the Homeobox domain of Prox1. |
| Specificity | This antibody is reactive with Prox-1. It will be a useful tool to study lymphatic vessel density in and around Human tumors. It will detect Prox-1 in the nucleus of lymphatic endothelial cells by Immunostaining or Immunohistochemistry. |
| Buffer | State: Serum State: Whole Serum containing 50% Glycerol. |
| Conjugation | Unconjugated |
| Storage | Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | prospero homeobox 1 |
| Database Link | |
| Background | The homeobox gene Prox-1 was originally cloned by homology to the Drosophila melanogaster gene prospero. Prox-1 is expressed in a subpopulation of endothelial cells which by budding and sprouting, give rise to the lymphatic system. Prox-1-deficient homozygous mice have unaffected vasculogenesis and angiogenesis, but liver and lymphatics do not develop. Human Prox-1 gene has been mapped to chromosome 1q32.2-q32.3, and its product shows 94% similarity to the chicken protein. The conserved structure and expression pattern of the Prox-1 gene imply that it may play the same roles in humans as in other vertebrates. The human Prox-1 gene is most actively expressed in the developing lens. Anti-Prox-1 antibodies provide a highly specific marker of lymphatic endothelial cells. |
| Synonyms | PROX1 |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
Reviews
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Citations
The proepicardium delivers hemangioblasts but not lymphangioblasts to the developing heart
Wilting, Buttler, Schulte et al
Dev Biol (2007) 305 (2), 451-9 DOI: 10.1016/j.ydbio.2007.02.026
Wilting, Buttler, Schulte et al
Dev Biol (2007) 305 (2), 451-9 DOI: 10.1016/j.ydbio.2007.02.026
Cited by 49
AI Summary: OriGene products, specifically the anti-Prox1 antibody (Cat# TA324937) and anti-LYVE1 antibody (Cat# TA327322), were used in this study to identify and characterize lymphatic endothelial cells and their origins in developing heart tissues.
First year changes of myocardial lymphatic endothelial markers in heart transplant recipients
Geissler, Dashkevich, Fischer et al
Eur J Cardiothorac Surg (2006) 29 (5), 767-71 DOI: 10.1016/j.ejcts.2005.12.024
Geissler, Dashkevich, Fischer et al
Eur J Cardiothorac Surg (2006) 29 (5), 767-71 DOI: 10.1016/j.ejcts.2005.12.024
Cited by 52
AI Summary: OriGene products contributed to this study by providing primary antibodies against VEGFR-3 (Cat# TA326169), LYVE-1 (Cat# TA327326), and PROX-1 (Cat# TA324936) for immunohistostaining to assess changes in myocardial lymphatic endothelial markers after heart transplantation.
Showing 1-2 of 2 papers.
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