LYVE1 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA, FC, IF, IHC, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry on Frozen and Paraffin Embedded Sections (1-5 µg/ml). Heat mediated antigen retrieval is recommended when staining paraffin embedded sections. Western blot (1-2 µg/ml). ELISA (1-15 µg/ml). Flow Cytometry (3-20 µg/ml). |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Highly pure recombinant Human soluble LYVE-1 produced in insect cells (Cat.-No DA3525). It consists of amino acid 24 (Ser) to 232 (Gly) and is fused to a C-terminal His-tag (6xHis). |
| Specificity | This antibody will detect LYVE-1 on the surface of lymphatic endothelial cells by Immunohistochemistry. It detects a 70 kD LYVE-1 band in Western blotting. This antibody is not reactive with Mouse LYVE-1. |
| Buffer | PBS, pH 7.2 without preservatives or stabilizers State: Aff - Purified State: Lyophilized purified IgG fraction |
| Reconstitution Method | Restore in sterile water to a concentration of 0.1-1.0 mg/ml |
| Purification | Antigen Affinity Chromatography |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Predicted Protein Size | ~50 kDa HC and ~25 kDa LC |
| Gene Name | lymphatic vessel endothelial hyaluronan receptor 1 |
| Database Link | |
| Background | LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosamino-glycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels. |
| Synonyms | LYVE1, CRSBP-1, CRSBP1, HAR, XLKD1 |
| Reference Data | |
| Protein Categories | Membrane Proteins |
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Citations
The cell-cell junctions of mammalian testes. III. Absence of an endothelial cell layer covering the peritubular wall of the seminiferous tubules-an immunocytochemical correction of a 50-year-old error in the literature
Franke, Domke, Dörflinger et al
Cell Tissue Res. (2019)
Franke, Domke, Dörflinger et al
Cell Tissue Res. (2019)
AI Summary: The paper does not mention or utilize any OriGene products.
Snippet: Mertens et al. 1996 pcl, gp (cl. GP-PP2)* Progen Biotechnik, GP-PP2 pcl, rb Acris Antibodies, APO1493PU-N pcl, gp (cl. SR2A)* Authors' laboratory LYVE-1 (lymph vessel endothelium hyaluronan receptor 1) pcl, rb Acris Antibodies, DP3500PS Banerji et al. 1999;Prevo
Showing 1-1 of 1 papers.
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