NCF4 Mouse Monoclonal Antibody [Clone ID: OTI3E3]
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI3E3 |
|---|---|
| Application | WB |
| Recommended Dilution | WB 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human NCF4 (NP_000622) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 38.9 kDa |
| Gene Name | neutrophil cytosolic factor 4 |
| Database Link | |
| Background | The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. provided by RefSeq, Jul 2008 |
| Synonyms | NCF; P40PHOX; SH3PXD4 |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins |
| Protein Pathways | Leukocyte transendothelial migration |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI3E3" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA809196 | NCF4 mouse monoclonal antibody,clone OTI3E3 | 100 ul |
$447.00
|
|
| TA809196AM | NCF4 mouse monoclonal antibody,clone OTI3E3, Biotinylated | 100 ul |
$509.00
|
|
| TA809196BM | NCF4 mouse monoclonal antibody,clone OTI3E3, HRP conjugated | 100 ul |
$509.00
|
|
| TA809196S | NCF4 mouse monoclonal antibody,clone OTI3E3 | 30 ul |
$200.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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