DRP1 (DNM1L) Mouse Monoclonal Antibody [Clone ID: OTI4F6]
SKU
CF506153
Carrier-free (BSA/glycerol-free) DNM1L mouse monoclonal antibody, clone OTI4F6 (formerly 4F6)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI4F6 |
|---|---|
| Application | IHC, Simple Western, WB |
| Recommended Dilution | WB 1:200~4000, IHC 1:150 ; Simple Western 1:20-1:50 |
| Reactivity | Dog, Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human DNM1L(NP_036192) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 81.7 kDa |
| Gene Name | dynamin 1 like |
| Database Link | |
| Background | The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. provided by RefSeq, Jul 2008 |
| Synonyms | DLP1; DRP1; DVLP; DYMPLE; EMPF; EMPF1; HDYNIV |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Nervous system Diseases |
| Protein Pathways | Endocytosis, Fc gamma R-mediated phagocytosis |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4F6" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA506153 | DNM1L mouse monoclonal antibody, clone OTI4F6 (formerly 4F6) | 100 ul |
$447.00
|
|
| TA506153AM | DNM1L mouse monoclonal antibody,clone 4F6, Biotinylated | 100 ul |
$509.00
|
|
| TA506153BM | DNM1L mouse monoclonal antibody,clone 4F6, HRP conjugated | 100 ul |
$509.00
|
|
| TA506153S | DNM1L mouse monoclonal antibody, clone OTI4F6 (formerly 4F6) | 30 ul |
$200.00
|
|
Citations
TEGDMA Releasing in Resin Composites with Different Filler Contents and Its Correlation with Mitochondrial Mediated Cytotoxicity in Human Gingival Fibroblasts
Liu, Gan, Zhao et al
J Biomed Mater Res A (2018)
Liu, Gan, Zhao et al
J Biomed Mater Res A (2018)
AI Summary: OriGene's rabbit anti-Drp-1 antibody (#TA506153) was used in this study to detect the expression of mitochondrial fission protein Drp-1, helping to assess mitochondrial function changes in human gingival fibroblasts exposed to TEGDMA from resin composites.
Snippet: After blocked, the membranes were incubated with different primary antibodies in 4 °C overnight, namely rabbit anti-Drp-1(1:1000, #TA506153, Origene), anti-Mfn2 (1:1000, #2433629, Millipore) and mouse anti-β-actin (1:8000, #ab6276, ABCam)
Drp1-dependent mitochondrial fission mediates osteogenic dysfunction in inflammation through elevated production of reactive oxygen species
Zhang, Gan, He et al
PLoS ONE (2017) 12 (4), e0175262 DOI: 10.1371/journal.pone.0175262
Zhang, Gan, He et al
PLoS ONE (2017) 12 (4), e0175262 DOI: 10.1371/journal.pone.0175262
AI Summary: In this study, the OriGene mouse anti-Drp1 antibody was used to detect Drp1 protein levels by Western blot, helping to assess the role of Drp1-dependent mitochondrial fission in osteogenic dysfunction under inflammatory conditions.
Snippet: membrane (Bio-Rad, Hercules, USA). The membrane was incubated with mouse anti-Drp1 antibody (1:1000;Origene, Rockville, MD, USA), and mouse anti-actin antibody (1:500;Millipore). After washing, the membrane was ... All 4 versions Cite SaveSaving
The cyclophilin D/Drp1 axis regulates mitochondrial fission contributing to oxidative stress-induced mitochondrial dysfunctions in SH-SY5Y cells
Xiao, Gan, Chen et al
Biochem. Biophys. Res. Commun. (2016)
Xiao, Gan, Chen et al
Biochem. Biophys. Res. Commun. (2016)
Reactive oxygen species regulatory mechanisms associated with rapid response of MC3T3-E1 cells for vibration stress
Zhang, Gan, Zhu et al
Biochem. Biophys. Res. Commun. (2016)
Zhang, Gan, Zhu et al
Biochem. Biophys. Res. Commun. (2016)
Cited by 11
AI Summary: OriGene's mouse anti-Drp1 antibody was used in this study to detect Drp1 protein levels, helping to elucidate the role of ERK-Drp1 signaling in the rapid response of MC3T3-E1 osteoblast cells to vibration-induced reactive oxygen species.
Snippet: The membrane was incubated with either mouse anti-ERK1/2 antibody (1:1000;R&D systems, Minneapolis, MN, USA), rabbit anti-p-ERK1/2 antibody (1:1000;Immunoway, Newark, DE, USA), mouse anti-Drp1 antibody (1:1000;Origene, Rockville, MD, USA), mouse ... Cite SaveSaving
Showing 1-4 of 4 papers.
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