Calca Goat Polyclonal Antibody

SKU BP022

Calca goat polyclonal antibody, Purified

Product Data

• Application: ELISA, IF, IHC
• Recommended Dilution: ELISA: 1/500-1/2500.; Immunofluorescence. ; Immunohistochemistry on Frozen Sections.; Immunohistochemistry on Paraffin Sections.
• Reactivity: Guinea Pig, Mouse, Rat, Reptiles
• Antibody Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic Rat Tyr-CGRP (23-37) conjugated to gamma Globulin
• Specificity: Recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and may play a role in migraine.; This antibody is reactive with both whole molecule (1-37) and the C-terminal fragment (23-37).; Specifically visualises CGRP in brain cells.
• Buffer: PBS; State: Purified; State: Liquid purified IgG fraction; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: calcitonin-related polypeptide alpha
• Database Link:
  P01256
• Background: CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
• Synonyms: Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I
• Note: The antibody has been described to work with reptilian material.

Reference Data