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BRCA2 pSer3291 Rabbit Polyclonal Antibody

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SKU
AP55853PU-S
BRCA2 pSer3291 rabbit polyclonal antibody, Aff - Purified
Size:
50 ul 100 ul
Conjugation:
Unconjugated
  $330.00
2 Weeks*
Bulk/Customize

View other "BRCA2 or NP_000050.2" antibodies

Specifications
Specifications
Product Data
Application WB
Recommended Dilution Western blot: 1:500~1:1000.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2 (KLH-conjugated)
Specificity The antibody detects endogenous levels of BRCA2 only when phosphorylated at serine 3291.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
State: Aff - Purified
State: Liquid Ig fraction
Concentration lot specific
Purification Affinity chromatography using epitope-specific peptide
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size >350 kDa
Gene Name BRCA2, DNA repair associated
Database Link
Background Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.
Synonyms FACD
Reference Data
Protein Categories Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cardiovascular diseases, Cytokines, Intracellular Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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