PITRM1 (Center) Rabbit Polyclonal Antibody
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | ELISA: 1/1000. Western Blot: 1/100-1/500. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | Ig |
| Clonality | Polyclonal |
| Immunogen | KLH conjugated synthetic peptide between 497-526 amino acids from the Central region of human PITRM1 |
| Specificity | This antibody recognizes Human PITRM1 (Center). |
| Buffer | PBS containing 0.09% (W/V) Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction |
| Concentration | lot specific |
| Purification | Protein A column, followed by peptide affinity purification |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | pitrilysin metallopeptidase 1 |
| Database Link | |
| Background | ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. |
| Synonyms | Pitrilysin metalloproteinase 1, Metalloprotease 1, MP1, KIAA1104 |
| Note | Molecular Weight: 117455 Da |
| Reference Data | |
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