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MMP14 (C-term) Rabbit Polyclonal Antibody

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SKU
AP23330PU-N
MMP14 (C-term) rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $600.00
2 Weeks*
Bulk/Customize

View other "MMP14 or NP_004986" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Western blot: At 0.5-1μg/ml with the appropriate system to detect MMP14 in cells and tissues.
Immunohistochemistry on paraffin sections: At 1-2 μg/ml to detect MMP14 in formalin fixed and paraffin embedded tissues.
Immunohistochemistry on frozen sections: At 1-2 μg/ml to detect MMP14 in formalin or acetone fixed tissues.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide mapping at the C-terminal of human MMP14
Specificity This antibody detects MMP-14 (C-term).
Buffer 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Gene Name matrix metallopeptidase 14
Database Link
Background Matrix metalloproteinases (MMPs) are Zn(2+)-binding endopeptidases that degrade various components of the extracellular matrix (ECM). The MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. MMPs have different substrate specificities and are encoded by different genes. membrane-type matrix metalloproteinase (MMP14) may be an activator of pro-gelatinase A (MMP2) and is expressed in fibroblast cells during both wound healing and human cancer progression. Survivin, MMP2, MMP9, and MMP14 mRNA expression levels in clinically aggressive pigmented lesions were significantly higher than those in normal eutopic endometrium, and survivin gene expression in pigmented lesions was also higher than that in nonpigmented lesions (P less than 0.05). There was a close correlation between survivin and MMP2, MMP9, and MMP14 gene expression levels in 63 endometriotic tissues examined (P less than 0.01).
Synonyms Matrix metalloproteinase-14, MMP14, MMP-X1, Membrane-type-1 matrix metalloproteinase
Reference Data
Protein Categories Enzyme: Peptidases, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways GnRH signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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