PGA3 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | IHC:1/50-200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 281-330 of Human Pepsin A. |
| Specificity | This antibody detects endogenous levels of Pepsin protein. (region surrounding Met307) |
| Buffer | Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide |
| Concentration | 1.0 mg/ml |
| Purification | Affinity Chromatography using epitope-specific immunogen |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | ~42 kDa |
| Gene Name | pepsinogen 3, group I (pepsinogen A) |
| Database Link | |
| Background | Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for Pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. Pepsin A is a member of the subfamily A1 within the Pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. Pepsin A is inhibited by ovUS-1, a uterine Serpin. |
| Synonyms | Pepsin A, PGA, pepsinogen 3 group I, pepsinogen 4 group I, pepsinogen 5 group I, Pepsinogen A, PGA3, PGA4, PGA5 |
| Reference Data | |
| Protein Families | Druggable Genome |
Reviews
Documents
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Citations
Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma
Kushima, Sekine, Matsubara et al
Pathol Int (2013) 63 (6), 318-25 DOI: 10.1111/pin.12070
Kushima, Sekine, Matsubara et al
Pathol Int (2013) 63 (6), 318-25 DOI: 10.1111/pin.12070
Cited by 67
AI Summary: OriGene products, specifically the anti-MIST1 antibody (TA323509) and anti-MUC6 antibody (TA802025), were used in this study to perform immunohistochemical analyses that helped characterize the cellular differentiation and phenotypic features of gastric adenocarcinoma of the fundic gland type and pyloric gland adenoma.
Showing 1-1 of 1 papers.
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