Cripto1 (TDGF1) Goat Polyclonal Antibody
| Product Data | |
| Application | ELISA, IHC |
|---|---|
| Recommended Dilution | Peptide ELISA: 1/128000 (Detection Limit) Immunohistochemistry on Paraffin Sections: 3-5 µg/ml. In paraffin embedded Human Placenta shows staining assocated with nuclei in some trophoblasts and weak cytoplasm staining in cytotrophoblasts. |
| Reactivity | Bovine, Canine, Human, Mouse, Rat |
| Antibody Host | Goat |
| Clonality | Polyclonal |
| Immunogen | Peptide with sequence from the internal region of the protein sequence according to NP_003203.1. |
| Specificity | Recognizes CRIPTO |
| Buffer | Tris saline, pH~7.3 State: Aff - Purified State: Liquid purified IgG fraction Stabilizer: 0.5% BSA Preservative: 0.02% Sodium Azide |
| Concentration | lot specific |
| Purification | Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | teratocarcinoma-derived growth factor 1 |
| Database Link | |
| Background | Human Cripto-1 (CR-1), also known as Teratocarcinoma-derived growth factor 1 (TDGF1), is a member of the epidermal growth factor (EGF)-GFC family and has been implicated in both embryogenesis and carcinogenesis. During early vertebrate development, CR-1 functions as a co-receptor for Nodal, a transforming growth factor beta (TGFbeta) family member, and is essential for mesoderm and endoderm formation and anterior-posterior and left-right axis establishment. In adult tissues, CR-1 is expressed at a low level in all stages of mammary gland development, and expression increases during pregnancy and lactation. Over-expression of CR-1 in mouse mammary epithelial cells leads to their transformation in vitro, and when injected in mammary glands, CR-1 produces ductal hyperplasias. |
| Synonyms | Cripto-1 growth factor, CRGF |
| Reference Data | |
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