TAB1 Rabbit Polyclonal Antibody

CAT#: AP17544PU-N

TAB1 rabbit polyclonal antibody

Product Images

Western blot analysis of MAP3K7IP1 (arrow) using rabbit polyclonal MAP3K7IP1-pS423. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAP3K7IP1 gene (Lane 2) (Origene Technologies).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1,000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide selected from the amino acid residues surrounding S423 of human MAP3K7IP1
• Specificity: This antibody reacts to MAP3K7IP1.
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Liquid purified Ig
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
• Database Link:
  Entrez Gene 10454 Human
  UniProt ID Q15750
• Background: MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.
• Synonyms: TAK1-binding protein 1, TGF-beta-activated kinase 1-binding protein 1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway