BACE2 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-BACE2 Antibody, Purified
Product Datasheet for 'AP13084PU-N'
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human BACE2.|
|Formulation||PBS with 0.09% (W/V) sodium azide|
|Purification||Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Predicted Protein Size||49.8KDa|
|Gene Name||beta-site APP-cleaving enzyme 2|
|Background||Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by BACE2. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease.|
|Protein Families||Transmembrane, Protease, Druggable Genome|
|Protein Pathways||Alzheimer's disease|
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