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Fractin (C-term) Rabbit Polyclonal Antibody

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SKU
AP08647SU-N
Fractin (C-term) rabbit polyclonal antibody, Serum
Size:
100 ul
Conjugation:
Unconjugated
  $540.00
2 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Western Blot: 1/1000.
Immunohistochemistry: 1/100.
Reactivity Human, Rat
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide taken from the C terminus of the 32-kDa Actin fragment.
Specificity Specific for the ~ 32 kDa Fractin protein in Western blots with no reactivity to intact actin. There is often a ladder of smaller bands in cells or culture or in vivo preparations due to further degradation by other proteases.
The antibody has been shown to detect the processes and cell bodies of degenerating neurons and plaque-associated microglia in Alzheimer's disease. (Ref.1)
Buffer State: Serum
State: Liquid Neat Serum without preservatives.
Conjugation Unconjugated
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Background Fractin (fragment of Actin) is a Caspase-specific cleavage product of actin and serves as a novel marker of apoptosis-related events. It has recently been reported that Fractin may have a functional role in apoptotic signaling in oligodendrocytes (Schulz, R., et al., Glia, 2009, in press).
Synonyms Fragment of Actin
Reference Data
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Documents
Resources

file-alt Citations

Azithromycin preserves adult hippocampal neurogenesis and behavior in a mouse model of sepsis
Rodríguez-Moreno, Cañeque-Rufo, Flor-García et al
Brain Behav Immun (2024) 117, 135-148 DOI: 10.1016/j.bbi.2024.01.005
Cited by 15
AI Summary: In this study, OriGene’s anti-GFAP antibody (OriGene Cat# TA309156) was used to label and analyze astrocytes in the hippocampus, contributing to the assessment of neuroinflammatory and neurogenic changes following azithromycin treatment in a mouse model of sepsis.
Snippet: The mammalian hippocampus can generate new neurons throughout life. Known as adult hippocampal neurogenesis (AHN), this process participates in learning, memory;rabbit anti-Fractin (Acris Antibodies GmbH Cat# AP08647SU-N, RRID:AB_1975531;1:500);guinea pig anti-Doublecortin (DCX) (Synaptic systems Cat# 326004, RRID:AB_2620068
Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia
Terreros-Roncal, Flor-García, Moreno-Jiménez et al
J. Neurosci. (2019)
AI Summary: In this study, OriGene's rabbit anti-Fractin antibody (Acris Antibodies GmbH Cat# AP08647SU-N) was used to detect apoptotic cells, contributing to the analysis of neuronal alterations in the dentate granule cells of FTD patients and mouse models.
Snippet: Scientific Cat# 359 M11217, RRID:AB_2536611;1:2,500);mouse anti-IdU (Becton DicNinson and Company Cat# 360 347580, RRID:AB_10015219;1:500);rabbit anti-Fractin (Acris Antibodies GmbH Cat# 361 AP08647SU-N, RRID
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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