ATM Rabbit Polyclonal Antibody

CAT#: AP08052PU-S

ATM rabbit polyclonal antibody, Aff - Purified

Product Images

Figure 1. Western blot analysis of extract from 293T cells, using ATM Antibody.

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  Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using ATM Antibody (Red).

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western Blot: 1/500-1/1000.
  Immunofluorescence: 1/100-1/200.
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human ATM around the phosphorylation site of Serine 1981 (E-G-SP-Q-S).
• Specificity: ATM Antibody AP08052PU detects endogenous levels of total ATM protein.
• Formulation: PBS (without Mg²⁺ and Ca_²⁺), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: ATM serine/threonine kinase
• Database Link:
  Entrez Gene 472 Human
  UniProt ID Q13315
• Background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).
• Synonyms: Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATDC, TEL1, TELO1