MAP1 (MOAP1) Rabbit Polyclonal Antibody

SKU AP07773PU-N

MAP1 (MOAP1) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.; Western Blot: 1 µg/ml.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic Peptide corresponding to 15 amino acid peptide from near the center of human MAP-1.
• Specificity: This antibody recognises MAP-1 Protein (MOAP1).
• Buffer: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative.; State: Aff - Purified; State: Liquid purified IgG fraction.
• Concentration: lot specific
• Purification: Immunoaffinity Chromatography.
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or; (in aliquots) at -20°C to -70°C for longer.; Dilute only prior to immediate use.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: modulator of apoptosis 1
• Database Link:
  Q96BY2
• Background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
• Synonyms: MAP-1, MAP1, Modulator of apoptosis 1

Reference Data