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STAT2 Rabbit Polyclonal Antibody

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SKU
AP06326PU-N
STAT2 rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $495.00
7 Weeks*
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View other "STAT2 or NP_005410.1" antibodies

Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide, corresponding to amino acids 650-700 of Human Stat2.
Specificity This antibody detects endogenous levels of STAT2 protein.
(region surrounding Leu684)
Buffer Phosphate buffered saline (PBS), pH 7.2.
State: Aff - Purified
State: Liquid purified Ig fraction ()> 95% pure by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity-chromatography using epitope-specific immunogen
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Predicted Protein Size ~ 105, 113 kDa
Gene Name signal transducer and activator of transcription 2
Database Link
Background Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Synonyms p113
Reference Data
Protein Categories Cytokines, Growth Factors, Immune system diseases, Intracellular Proteins, Nervous system Diseases, Transciption Factors
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Documents
Resources

file-alt Citations

Local hyperthermia could induce antiviral activity by endogenous interferon-dependent pathway in condyloma acuminata
Zhu, Gao, Qi et al
Antiviral Res (2010) 88 (2), 187-92 DOI: 10.1016/j.antiviral.2010.08.012
Cited by 40
AI Summary: In this study, OriGene’s primers for IFN-α, IFN-β, IFN-γ, 2'-5' oligoadenylate synthase, dsRNA-dependent protein kinase, IFN-α/β receptor, Jak1, Tyk2, Stat1, and Stat2 were used to measure gene expression changes, demonstrating that local hyperthermia induces antiviral activity in condyloma acuminata through the endogenous interferon-dependent pathway.
Showing 1-1 of 1 papers.
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