RIT1 Rabbit Polyclonal Antibody
Other products for "RIT1"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | Western blot: 1/500-1/1000. |
Reactivities | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 170-220 of Human Rit1. |
Specificity | This antibody detects endogenous levels of ROC1 protein. (region surrounding Trp204) |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15 mM sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~ 25 kDa |
Gene Name | Ras like without CAAX 1 |
Database Link | |
Background | ROC 1 and ROC 2 are the two highly conserved RING finger proteins that are homologous to APC 11, a subunit of the anaphase promoting complex(APC). ROC 1 and ROC 2 commonly interact with all cullins while APC 11 specifically interacts with APC 2, a cullin related APC subunit. ROC 1 and APC 11 immunocomplexes can catalyze isopeptide ligations to form polyubiquitin chains in an E1 and E2 dependent manner. ROC 1 is thought to play a unique role in the ubiquitination reaction by heterodimerizing with cullin 1 to catalyze ubiquitin polymerization. |
Synonyms | RIBB, RIT, ROC1 |
Reference Data |
Documents
Product Manuals |
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