CREB1 Rabbit Polyclonal Antibody
Other products for "CREB1"
Specifications
Product Data | |
Applications | ELISA, IHC, WB |
Recommended Dilution | Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin sections: 1/50-1/200. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 100-150 of Human CREB. |
Specificity | This antibody detects endogenous levels of CREB1 protein (region surrounding Ile127). |
Formulation | Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15 mM Sodium azide |
Concentration | 1.0 mg/ml |
Purification | Affinity chromatography using epitope-specific immunogen (> 95% pure by SDS-PAGE). |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | ~38 kDa |
Gene Name | cAMP responsive element binding protein 1 |
Database Link | |
Background | Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. |
Synonyms | CREB-1 |
Reference Data |
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