DISC1 Rabbit Polyclonal Antibody

CAT#: AP05716PU-N

DISC1 rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of whole cell lysate from SK-N-SH human neuroblastoma cells probed with Rabbit anti Human DISC1 at 0.5 (A), 1 (B) and 2 (C) ug/ml

• 

  Immunocytochemical staining of HeLa cells with Rabbit anti Human DISC1

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: Western blot: 1 - 2 µg/ml; detects bands of approximately 95100kDa in SKNSH cell lysate.
  Immunocytochemistry.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: An 18 amino acid peptide located near the centre of human DISC1.
• Specificity: This antibody recognises disrupted in schizophrenia 1 (DISC1), 93kD protein located in the nucleus, cytoplasm and mitochondria.
• Formulation: Phosphate buffered saline containing 0.02% Sodium Azide
  State: Purified
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: disrupted in schizophrenia 1
• Database Link:
  Entrez Gene 27185 Human
  UniProt ID Q9NRI5
• Background: The DISC1 protein is widely expressed in normal tissues. It is involved in neurite outgrowth and cortical development through its interaction with a variety of proteins including lissencephaly-1 (LIS1), NudeE-like (NUDEL) and phosphodiesterase 4B.
  In certain cases of schizophrenia the DISC1 gene has been found to be disrupted by a t(1;11) (q42.1;q14.3) translocation, and studies suggest that DISC1 could be a candidate susceptibility gene for this condition.
• Synonyms: DISC-1, KIAA0457, Disrupted in schizophrenia 1 protein