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MEF2A pThr312 Rabbit Polyclonal Antibody

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SKU
AP01632PU-N
MEF2A pThr312 rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $525.00
7 Weeks*
Bulk/Customize

View other "MEF2A or NP_001124398.1" antibodies

Specifications
Specifications
Product Data
Application IHC, IP
Recommended Dilution IHC:1/50-200, IP:1/50-200
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of MEF2A protein only when phosphorylated at Thr312.
Buffer Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen.
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Shipping Blue Ice
Gene Name myocyte enhancer factor 2A
Database Link
Background MEF-2 is a muscle-specific DNA binding protein that recognizes an A+T-rich sequence CTA (A/T)4 TAG localized in the control regions of numerous muscle-specific genes. MEF-2 belongs to the MADS (MCM1, Agamous, Deficiens and serum-response factor) box family of transcription factors. The MEF-2 proteins arise from several alternatively spliced isoforms of the MEF-2 gene. MEF-2 expression is ubiquitous, but appears to be preferential in skeletal and cardiac muscle cells. Phosphorylation of different MEF-2C isoforms affects their expression pattern and transactivation function. Big MAP kinase 1 (BMK1) enhances the transactivation activity of MEF-2C by phosphorylating Ser 387. Serum is a potent stimulator of BMK1-induced MEF-2C phosphorylation. p38 MAPK can phosphorylate MEF-2C at positions Ser 387, Thr 293 and Thr 300. Phosphorylation of MEF-2C by either p38 MAPK or ERK5/BMK1 is necessary for Smad-MEF-2 signaling cooperativity.
Synonyms MEF2, Myocyte-specific enhancer factor 2A
Note Molecular Weight: ~55.0 kDa
Reference Data
Protein Categories Cardiovascular diseases, Growth Factors, Intracellular Proteins, Transciption Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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