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ATF2 pSer62/44 Rabbit Polyclonal Antibody

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SKU
AP01529PU-N
ATF2 pSer62/44 rabbit polyclonal antibody, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $525.00
7 Weeks*
Bulk/Customize

View other "ATF2 or NP_001871.2" antibodies

Specifications
Specifications
Product Data
Application IHC, IP
Recommended Dilution IHC:1/50-200, IP:1/50-200
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Specificity p-ATF2 (pSer62/44) antibody detects endogenous levels of p-ATF2 protein.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
State: Aff - Purified
State: Liquid purified Ig
Concentration 1,0 mg/ml
Purification Affinity chromatography
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name activating transcription factor 2
Database Link
Background Eukaryotic gene transcription is regulated by sequence-specific transcription factors that bind modular cis acting promoter and enhancer elements. The ATF/ CREB transcription factor family binds the palindromic cAMP response element (CRE) octanucleotide TGACGTCA. The ATF/CREB family includes CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3. This family of proteins contain highly divergent N-terminal domains, but share a C-terminal leucine zipper for dimerization and DNA binding. ATF-1 is shown to play a key role in the induction of NOX1, this protein binds the cAMP response element (CRE) and mediates PKA-induced stimulation of CRE-reporter genes. ATF-2 forms homodimers and heterodimers with c-Jun to initiate CREdependent transcription. Phosphorylation of ATF-2 at Thr 69 and Thr 71 by stress-activated kinases is necessary for transcriptional activation. Myc also induces phosphorylation of ATF-2 at Thr 69 and Thr 71 to prolong the half-life of ATF-2. ATF-2 functions as a histone acetyltransferase (HAT) and acetylates Histones H2B and H4 specifically in vitro.
Synonyms ATF-2, CREB2, CREBP1, Activating transcription factor 2, CRE-BP1, HB16, CREB-2
Reference Data
Protein Categories Growth Factors, Intracellular Proteins, Transciption Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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