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PLAT Rabbit Polyclonal Antibody

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SKU
AP00892PU-N
PLAT rabbit polyclonal antibody, Purified
Size:
200 ug
Conjugation:
Unconjugated
  $875.00
2 Weeks*
Bulk/Customize

View other "PLAT or NP_000921.1" antibodies

Specifications
Specifications
Product Data
Application ELISA, IHC, WB
Recommended Dilution ELISA: 1/10,000-1/100,000.
Western blot: 1/1,000-1/10,000.
Immunohistochemistry: 1/100-1/1,000 for Frozen, Parafolmaldehyde-Fixed Sections.
Recommended pair for Sandwich Immunoassay:
Capture: AM05122PU-N
Detection: AP00892PU-N.
Reactivity Human
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Recombinant human tPA
Specificity This antibody recognizes tPA.
Buffer 0.05M Sodium Phosphate, pH 6.6 containing 0.1M Sodium Chloride and 1mM EDTA
State: Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Store the antibody at -70°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name plasminogen activator, tissue type
Database Link
Background TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, cell migration and many other physiopathological events. TPA binds to fibrin with high affinity; this leads to an increase in the catalytic efficiency of the enzyme of 100- to 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binding to laminin and fibronectin has also been demonstrated. TPA also binds to mannose receptor and the low density lipoprotein receptor related protein (LRP1). These proteins are involved in TPA clearance. TPA binds to annexin II and to cytokeratin 8. As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. Binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.
Synonyms tPA, Tissue-type plasminogen activator, Alteplase, Reteplase
Reference Data
Protein Categories Enzyme: Peptidases, Growth Factors, Secreated Proteins
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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