Complement C5 (C5) Mouse Monoclonal Antibody [Clone ID: 2952]
$665.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | 2952 |
|---|---|
| Application | ELISA, FN, IHC, WB |
| Recommended Dilution | Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50. Immunohistochemistry on paraffin sections: The typical starting working dilution is 1:50. Functional assays. Immunoassays. Western blot: The typical starting working dilution is 1:50. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Specificity | Monoclonal antibody 2952 reacts with a neo-epitope on C5a (des-Arg) that is formed upon cleavage of C5 into C5a and C5b. |
| Buffer | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin |
| Concentration | lot specific |
| Purification | Protein G |
| Conjugation | Unconjugated |
| Storage | Store at 2 - 8 °C. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | complement component 5 |
| Database Link | |
| Background | C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-alpha IL-1beta, IL-6 and IL-8. |
| Synonyms | CPAMD4, Complement component 5 |
| Reference Data | |
| Protein Categories | Chemokines, Growth Factors, Immune system diseases, Intracellular Proteins, Secreated Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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