ACE2 Human shRNA Plasmid Kit (Locus ID 59272) (Angiotensin Converting Enzyme 2)
SKU
TR306881
ACE2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 59272 |
|---|---|
| Synonyms | ACEH |
| Vector | pRS |
| E. coli Selection | Ampicillin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ACE2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 59272). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
| RefSeq | NM_021804, NM_021804.1, NM_021804.2, BC048094, BC048094.1, BC032938, BC039902, BC048144, BC059378 |
| UniProt ID | Q9BYF1 |
| Summary | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. provided by RefSeq, Nov 2020 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion
Cui, Cui, Liu et al
Nat Commun (2025) 16 (1), 6174 DOI: 10.1038/s41467-025-61230-1
Cui, Cui, Liu et al
Nat Commun (2025) 16 (1), 6174 DOI: 10.1038/s41467-025-61230-1
Cited by 25
AI Summary: OriGene's ACE2-shRNA-Puro plasmid (Cat no: TR306881) was used in this study to facilitate gene silencing and the construction of engineered cell lines for developing bioengineered nanovesicles for efficient siRNA delivery.
Snippet: r. The plasmid map of S protein was shown in Supplementary Fig. 1. Successful plasmid construction was confirmed through gene sequencing. Other plasmids, including ACE2-shRNA-Puro (Cat no: TR306881, Origene), S-pLVX-Hyg, SWT-pLVX-Hyg, SDM-pLVX-Hyg, human-ACE2-pLVX-Puro, EGFP-pLVX-Hyg and Luc-pLVX-Hyg were also constructed using lentiviral transfection approach. Lentiviral plasmid, packaging plasm
Showing 1-1 of 1 papers.
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