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Scrambled shRNA control in pGFP-C-shLenti shRNA Vector

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SKU
TR30021
29-mer Scrambled shRNA Cassette in pGFP-C-shLenti Vector, 5 ug
  $270.00
In Stock*
Specifications
Specifications
Product Data
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Download Vector Sequence
Storage Store the vector DNA at -20°C.
Stability Vector DNA is stable for at least one year from date of receipt when stored at -20°C.
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A Hypoxia Associated STC2 High Endothelial Subpopulation is Linked to Lipid Metabolic Reprogramming, Pathological Angiogenesis, and Immune Remodeling in Head and Neck Squamous Cell Carcinoma
Chen, Qin, Liu et al
Int J Gen Med (2026) 19, 619908 DOI: 10.2147/IJGM.S619908
AI Summary: OriGene's STC2 Human shRNA Plasmid Kit (Cat# TL309053) and scrambled shRNA negative control (TR30021) were used to knock down STC2 expression in HUVECs, enabling the study to assess the functional role of STC2 in endothelial cell viability, migration, and angiogenesis in head and neck squamous cell carcinoma.
Snippet: d 0.03–0.05 mg/mL endothelial cell growth supplement (ECGS) at 37 °C with 5% CO2.For STC2 knockdown, HUVECs were transfected with the STC2 Human shRNA Plasmid Kit (Cat# TL309053, Origene, USA), which contained four distinct 29-mer shRNA lentiviral GFP constructs targeting human STC2 (Gene ID: 8614) and a scrambled non-targeting shRNA negative control (TR30021) provided by the
FigureFigureFigure
PDCD10-Deficient Tumor Cells Reprogram Angiogenesis Through Paracrine Endothelial Activation and GSC-like Plasticity in GBM
Chen, Chen, Wan et al
Cells (2026) 15 (17), 1532-1532 DOI: 10.3390/cells15171532
AI Summary: OriGene products, specifically the lentiviral shRNA vector for PDCD10 knockdown (cat# TL302576) and the empty vector control (cat# TR30021), were used to generate stable PDCD10-deficient and control T98G glioblastoma cell lines, enabling the study of PDCD10’s role in GBM angiogenesis and cellular plasticity.
Snippet: Briefly, the inducible TRIPZ lentiviral shRNA vector targeting human PDCD10 (shPDCD10;Thermo Scientific;clone ID: V2THS_217165) was used to transduce U87 cells (shU87). A second lentiviral shRNA vector (OriGene, Rockville, MD, USA;cat# TL302576) was used for stable knockdown of PDCD10 in T98G cells (shT98G). Empty vector-transduced U87 (evU87;Thermo Scientific, Waltham, MA, USA;cat# RHS4750) and T98G (evT98G;OriGene;cat# TR30021) cells
Targeting a novel metabolic vulnerability of non-small cell lung cancer to fatty acid oxidation surmounts chemoresistance
Fontana, Belisario, Giannotta et al
Drug Resist Updat (2026) 89, 101462 DOI: 10.1016/j.drup.2026.101462
Cited by 1
AI Summary: OriGene products, specifically the GFP-lentiviral shRNA plasmids targeting CPT1A (TR313747), LAP (TL320301), ABCB1 (TL315032V), ABCC1 (TL306920V), ABCC2 (TL315026V), and a scrambled control (TR30021), were used for gene silencing to investigate the roles of these genes in chemoresistance and metabolic reprogramming in NSCLC cells.
Snippet: For gene silencing, 1 × 105 cells were transduced with 1 μg of a GFP-lentiviral plasmid containing a non-relevant 29-mer scrambled shRNA cassette (TR30021), a sequence targeting CPT1A (TR313747), LAP (TL320301), ABCB1 (TL315032V), ABCC1 (TL306920V) or ABCC2 (TL315026V;all from Origene, Rockville, MD)
L1CAM signaling through planar cell polarity drives SOX2 expression and lung adenocarcinoma metastasis
Park, Kaygusuz, Kenum et al
Nat Commun (2026)
Cited by 2
AI Summary: OriGene’s scrambled shRNA control (Cat# TR30021) was used to generate control cells for viral transduction experiments, enabling the study of L1CAM signaling in lung adenocarcinoma metastasis.
Snippet: ShControl cells were generated in both cases by transducing the cells with scrambled shRNA control (Origene Cat# TR30021). Viral transductions were performed as
Nitric Oxide, Reactive Oxygen Species, and Focal Adhesion Kinase Mediate Anoikis Resistance in A375 and SK-MEL-28 Human Melanoma Cells
Nascimento, Teodoro, Sousa et al
Antioxidants (Basel) (2026) 15 (6), 740-740 DOI: 10.3390/antiox15060740
AI Summary: OriGene products, specifically the NOS2 shRNA construct (HC137047) and the Scramble control (TR30021), were used to generate stable NOS2 knockdown in A375 melanoma cells, enabling the study of nitric oxide's role in anoikis resistance.
Snippet: le>To generate stable A375 cells knockdown for NOS2, short hairpin RNA (shRNA) sequences against the NOS2 gene and the Scramble control (TR30021), were obtained from (Origene Technologies, Rockville, MD, USA). The sequence used was: iNOS _ SH construct: GCTATCGAATTTGTCAACC (HC137047). HEK 293T cells plated in 24-well plates at 2  ×  104 cell dens
FigureFigureFigure
Hippocalcin Regulates NMDA Receptor Function and Neuronal Activity Through Elavl3 in Mouse Hippocampal Neural Precursor Cells
Kang, Jung, Son et al
Int J Mol Sci (2026) 27 (5), 2439-2439 DOI: 10.3390/ijms27052439
AI Summary: OriGene’s Elavl3-targeting 29-mer shRNA (Cat# TL512545) and scrambled control shRNA (Cat# TR30021) were used to manipulate gene expression in mouse hippocampal neural precursor cells, enabling the study of Elavl3’s role in NMDA receptor function and neuronal activity.
Snippet: ique 29-mer shRNA constructs designed to target mouse Elavl3 (Cat# TL512545) and non-effective 29-mer scrambled negative control shRNA (Cat# TR30021) were purchased from OriGene Technologies Inc. (Rockville, MD, USA). Lentiviral particles were produced by co-transfection of control or Hpca shRNA with lentiviral packaging plasmids, pLP1, p
FigureFigureFigure
Showing 1-6 of 102 papers.
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