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CEBP Alpha (CEBPA) (NM_004364) Human Recombinant Protein

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SKU
TP760685
Purified recombinant protein of Human CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

TA374612 CEBPA Rabbit polyclonal Antibody
100 ul
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Other products for "CEBP Alpha or NM_004364"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length CEBPA
Tag N-His
Predicted MW 37.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Bioactivity Binding assay (PMID: 29636686)
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_004355
Locus ID 1050
UniProt ID P49715
Cytogenetics 19q13.11
RefSeq Size 2385
RefSeq ORF 1074
Synonyms C/EBP-alpha; CEBP
Summary This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. provided by RefSeq, Dec 2013
Protein Categories Cancer: Haematopoietic and Lymphoid, Cytokines, Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, ES Cell Differentiation/IPS
Protein Pathways Acute myeloid leukemia, Pathways in cancer
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Other "CEBP Alpha" proteins (2)
SKU Description Size Price
LC418038 Lyophilized CEBPA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY418038 Transient overexpression lysate of CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA) (as WB positive control) 100 ug
$436.00

file-alt Citations

Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation
Lopez-Pajares, Bhaduri, Zhao et al
Cell Stem Cell (2025)
Cited by 14
AI Summary: OriGene products—specifically human recombinant IRF6 (Cat# TP301579), OVOL1 (Cat# TP760794), CEBPA (Cat# TP760685), and HK1 (Cat# TP300464)—were used to investigate the direct binding of glucose to regulatory proteins and assess their roles in epidermal differentiation.
Snippet: Sephadex G100 resin Edvotek Cat# 277 Alexa Fluor 488 Phalloidin Invitrogen Cat# A12379 Human recombinant IRF6 Origene Cat# TP301579 Human recombinant OVOL1 Origene Cat# TP760794 Human recombinant CEBPA Origene Cat# TP760685 Human recombinant HK1 Origene Cat# TP300464
Multiscale footprints reveal the organization of cis-regulatory elements
Hu, Horlbeck, Zhang et al
Nature (2025) 638 (8051), 779-786 DOI: 10.1038/s41586-024-08443-4
Cited by 60
AI Summary: OriGene’s recombinant CEBPA protein (catalogue no. TP760685) was used in this study to investigate DNA-protein interactions at cis-regulatory elements, enabling analysis of transcription factor binding footprints as part of the PRINT method.
Snippet: with either recombinant c-MYC/MAX (Active Motif, catalogue no. 81087) or CEBPA (OriGene, catalogue no. TP760685), tagmentation buffer (20 mM Tris, 10 mM MgCl2 and 20% dimethylformamide) and water in a 40-μl volume at room temperature for 1 h. Next, a master mix consi
FigureFigureFigure
High-Resolution Dissection of Cis-Regulatory Elements
Hu
Thesis (2025)
AI Summary: OriGene's recombinant CEBPA protein (catalogue no. TP760685) was used to incubate with DNA, enabling the study of cis-regulatory element interactions in the experimental workflow.
Snippet: AC DNA (50 ng) was incubated with either recombinant c-MYC/MAX (Active Motif, catalogue no. 81087) or CEBPA (OriGene, catalogue no. TP760685), tagmentation buffer (20 mM Tris, 10 mM MgCl2 and 20% dimethylformamide) and water in a 40-μl volume at room temperature for 1 h. Next, a master mix consisting of 0.15 μl of preassembled Tn5 (seqWell, Tagify(TM)), 4.85 μl of dilution buffer (50
Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBPα and PPARα
Sun, Tan, Lu et al
Front Pharmacol (2018) 9, 268 DOI: 10.3389/fphar.2018.00268
AI Summary: OriGene products, specifically the C/EBPα (Cat# RC209347) and PPARα (Cat# RC210731) expression plasmids, were used in this study to investigate the molecular mechanisms by which arctigenin inhibits gankyrin expression and liver cancer cell growth.
FigureFigureFigure
Showing 1-4 of 4 papers.
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