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MGP (NM_000900) Human Recombinant Protein

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SKU
TP760483
Purified recombinant protein of Human matrix Gla protein (MGP), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length MGP
Tag N-His
Predicted MW 12.2 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000891
Locus ID 4256
UniProt ID P08493
Cytogenetics 12p12.3
RefSeq Size 1398
RefSeq ORF 309
Synonyms GIG36; MGLAP; NTI
Summary This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. provided by RefSeq, Sep 2016
Protein Categories Intracellular Proteins, Secreated Proteins
Protein Families Secreted Protein
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Other "MGP" proteins (2)
SKU Description Size Price
LC400323 Lyophilized MGP HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400323 Transient overexpression lysate of matrix Gla protein (MGP) (as WB positive control) 100 ug
$436.00

file-alt Citations

Breast cancer remodels lymphatics in sentinel lymph nodes
Eichin, Lehotina, Kauko et al
Nat Commun (2025) 16 (1), 10056 DOI: 10.1038/s41467-025-64981-z
Cited by 7
AI Summary: In this study, OriGene's recombinant Matrix Gla protein (MGP, TP760483) was used in vitro to investigate the role of MGP in lymphatic endothelial cell remodeling and cancer cell adhesion within sentinel lymph nodes affected by breast cancer.
Snippet: vitro experiments Reagents were obtained from different manufacturers. VEGF-C (100-20CD), VEGF165 (100-20), M-CSF, GM-CSF, and G-CSF were obtained from Peprotech, and MGP (TP760483) was obtained from Origene. AACOCF3 (ab120350) was obtained from Abcam, fludarabine (S1491) from Seleckchem, antibodies targeting adrenomedullin (AF6108), EGF (AB-236NA), goat IgG control (AB-108-C), PDGF (AB-20-NA), ra
FigureFigureFigure
Showing 1-1 of 1 papers.
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