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ATF 4 (ATF4) (NM_001675) Human Recombinant Protein

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SKU
TP760367
Purified recombinant protein of Human activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
4 Weeks*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length ATF4
Tag N-His
Predicted MW 38.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001666
Locus ID 468
UniProt ID P18848
Cytogenetics 22q13.1
RefSeq Size 2022
RefSeq ORF 1053
Synonyms CREB-2; CREB2; TAXREB67; TXREB
Summary This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. provided by RefSeq, Sep 2011
Protein Categories Growth Factors, Intracellular Proteins, Transciption Factors
Protein Families Transcription Factors
Protein Pathways GnRH signaling pathway, Long-term potentiation, MAPK signaling pathway, Neurotrophin signaling pathway, Prostate cancer
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Documents
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Other "ATF 4" proteins (1)
SKU Description Size Price
TP760908 Purified recombinant protein of Human activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug 50 ug
$270.00

file-alt Citations

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial
Flores, Yu, Cohen et al
Nat Commun (2025) 16 (1), 7690 DOI: 10.1038/s41467-025-63031-y
Cited by 21
Snippet:  μg/mL Biotinylated Mouse anti-CREB-2 coating antibody diluted in Diluent 100 (MSD, #R50AA-2) was added and the plate was incubated at RT for 1 h on an orbital shaker at 700 rpm. ATF4 protein (Origene, TP760367) calibration standards were prepared in 1/50 Diluted Jurkat Cell Lysates (1×107 cells/mL) using CST lysis buffer at 3X dilutions between 360 pg/mL and 10 pg/mL and then 2x dilut
FigureFigureFigure
Showing 1-1 of 1 papers.
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