RALB Mouse Monoclonal Antibody [Clone ID: OTI2C4]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI2C4 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:200~4000, IHC 1:150, IF 1:100 |
| Reactivity | Dog, Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human RALB(NP_002872) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 23.2 kDa |
| Gene Name | RAS like proto-oncogene B |
| Database Link | |
| Background | This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. provided by RefSeq, Jul 2008 |
| Synonyms | GTP binding protein; GTP binding protein); RAS-like protein B; v-ral simian leukemia viral oncogene homolog B; v-ral simian leukemia viral oncogene homolog B (ras related |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Pancreatic cancer, Pathways in cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2C4" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF505880 | Carrier-free (BSA/glycerol-free) RALB mouse monoclonal antibody, clone OTI2C4 (formerly 2C4) | 100 ug |
$620.00
|
|
| TA505880AM | RALB mouse monoclonal antibody,clone 2C4, Biotinylated | 100 ul |
$509.00
|
|
| TA505880BM | RALB mouse monoclonal antibody,clone 2C4, HRP conjugated | 100 ul |
$509.00
|
|
| TA505880S | RALB mouse monoclonal antibody, clone OTI2C4 (formerly 2C4) | 30 ul |
$200.00
|
|
Citations
Structure and mechanism of the RalGAP tumor suppressor complex
Rasche, Klink, Apken et al
Nat Commun (2025) 16 (1), 7002 DOI: 10.1038/s41467-025-61743-9
Rasche, Klink, Apken et al
Nat Commun (2025) 16 (1), 7002 DOI: 10.1038/s41467-025-61743-9
Cited by 3
AI Summary: In this study, the OriGene anti-RalB antibody (OTI2C4, TA505880) was used to detect RalB protein, contributing to the characterization of the RalGAP tumor suppressor complex.
Snippet: The following primary antibodies were used: anti-RalA (Proteintech, 13629-1-AP), anti-RalB (OTI2C4, Origene, TA505880), anti-RGβ (Proteintech, 28330-1-AP) anti-ALFA (Nanotag, N1582), anti-FLAG (clone M2, Sigma-Aldrich, F1804), anti-HA (clone C29F4, Cell Signaling Technology, 3742), anti-HA (clone 16B12, Biolegend) and anti-κB-Ras (provided by S. Ghosh, Columbia University26)
The GTPase κB-Ras is an essential subunit of the RalGAP tumor suppressor complex
Rasche, Apken, Titze et al
J Biol Chem (2025) 301 (8), 110460 DOI: 10.1016/j.jbc.2025.110460
Rasche, Apken, Titze et al
J Biol Chem (2025) 301 (8), 110460 DOI: 10.1016/j.jbc.2025.110460
Cited by 1
AI Summary: In this study, the OriGene anti-RalB antibody (catalog no.: TA505880) was used for immunoblotting to detect RalB protein levels, contributing to the analysis of RalGAP complex components and their role in tumor suppression.
Snippet: resuspended in 1x SDS loading dye. Antibodies The following antibodies were used for immunoblotting: α-RalA (1:1000 dilution;Proteintech, catalog no.: 13629-1-AP), α-RalB (1:1000 dilution, OTI2C4;Origene, catalog no.: TA505880), α-κB-Ras (1:1000 dilution, provided by S. Ghosh, Columbia University (18)), α-ALFA (1:2000 dilution;Nanotag, catalog no.: N1582), α-FLAG (1:2000 dilution;clone M
Structure and mechanism of the RalGAP tumor suppressor complex
Rasche, Klink, Apken et al
bioRxiv (2024)
Rasche, Klink, Apken et al
bioRxiv (2024)
Cited by 1
Snippet: The following primary antibodies were used: anti-RalA (Proteintech, 13629-1-AP), anti-RalB (OTI2C4, Origene, TA505880), anti-ALFA (Nanotag, N1582), anti-FLAG (clone M2, Sigma-Aldrich, F1804), anti-HA (clone C29F4, Cell Signaling Technology, 3742), anti-HA (clone 16B12, Biolegend) and anti-κB-Ras (provided by S. Ghosh, Columbia University25)
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Beel, Kolloch, Apken et al
Nat Commun (2020) 11 (1), 3409 DOI: 10.1038/s41467-020-17226-0
Beel, Kolloch, Apken et al
Nat Commun (2020) 11 (1), 3409 DOI: 10.1038/s41467-020-17226-0
Cited by 39
AI Summary: OriGene products, including the RalA and RalB shRNA plasmids, were used in this study to specifically knock down Ral GTPase expression, enabling the authors to elucidate the role of Ral signalling in acinar-to-ductal metaplasia and pancreatic cancer progression.
Snippet: ) GTPase signalling pathway (Fig. 1a)7. Recent findings suggest a complex role of PI3K–Pdk1 signalling in PDAC. Constitutively active PI3K (PI3KCAH1047R) has been shown to mimic KRasG12D-driven tumorigenesis, while Pdk1 (3-phosphoinositide-dependent protein kinase-1) deletion in the KRasG12D-expressing pancreas blocked PanIN and PDAC development8,9. These findings are supported by the fact that
Showing 1-4 of 4 papers.
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