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ALKBH8 Rabbit Polyclonal Antibody

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SKU
TA365348
ALKBH8 rabbit polyclonal antibody
Size:
100 ul
Conjugation:
Unconjugated
  $310.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application IHC, WB
Recommended Dilution WB: 500-2000
WB positive control: A549 and Jurkat cell lysates
IHC: 25-100
Positive control: Human cervical cancer
Predicted cell location: Cytoplasm or Nucleus
Reactivity Human
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Full length fusion protein
Buffer pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C.
Stability 1 year
Shipping Blue Ice
Predicted Protein Size 75 kDa
Gene Name alkB homolog 8, tRNA methyltransferase
Database Link
Background ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
Synonyms ABH8; FLJ38204; MGC10235; OTTHUMP00000211286; OTTHUMP00000211287
Reference Data
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

ALKBH8-mediated codon-specific translation promotes colorectal tumorigenesis
Qian, Wu, Wei et al
Nat Commun (2025) 16 (1), 9075 DOI: 10.1038/s41467-025-64144-0
Cited by 3
AI Summary: OriGene’s anti-ALKBH8 antibody (TA365348) was used for immunofluorescence staining to assess ALKBH8 protein expression in colorectal cancer tissues, contributing to the study’s investigation of ALKBH8’s role in tumorigenesis.
Snippet: Reprogramming gene expression at the translational level drives intestinal tumorigenesis. Codon decoding during translation elongation relies on tRNA modifications,;tion, TA365348, Origene), KRAS (1/500 dilution, 16155-1-AP, Proteintech), Brdu (10 μg/mL, ab1893, Abcam), Ki67 (1/200 dilution, ab16667, Abcam), β-catenin (1/100 dilution, A2064, Abclonal). Immunofluorescence staining
FigureFigureFigure
IF
Showing 1-1 of 1 papers.
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