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Itgb2 Mouse siRNA Oligo Duplex (Locus ID 16414)

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SKU
SR419987
Itgb2 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "Itgb2 or NM_008404"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
Itgb2 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 16414)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_008404
UniProt ID P11835
Synonyms 2E6; AI528527; Cd18; LAD; LCAMB; Lfa1; MF17
Summary Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (By similarity). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (By similarity). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (By similarity). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). Integrin ITGAM/ITGB2 plays a critical role in mast cell development and in immune complex-mediated glomerulonephritis. Mice expressing a null mutation of the ITGAM subunit gene demonstrate increase in neutrophil accumulation, in response to a impaired degranulation and phagocytosis, events that apparently accelerate apoptosis in neutrophils. These mice develop obesity.UniProtKB/Swiss-Prot Function
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Force-bearing phagocytic adhesion rings mediate the phagocytosis of surface-bound particles
Kundu, Pal, Pyne et al
Nat Commun (2025) 16 (1), 984 DOI: 10.1038/s41467-025-56404-w
Cited by 12
AI Summary: OriGene products, including Itgb2 Mouse siRNA Oligo Duplex (SR419987), Itgb1 Mouse siRNA Oligo Duplex (SR427527), scrambled siRNA (SR30004), and dye-labeled siRNA (SR30002), were used to specifically knock down integrin β2 and β1 in macrophages, enabling the study of their roles in phagocytic adhesion ring formation and function.
Snippet: … After cell culture for 40 h, integrin β2 specific siRNA (Itgb2 Mouse siRNA Oligo Duplex, SR419987, Origene), integrin β1 specific siRNA (Itgb1 Mouse siRNA Oligo Duplex, SR427527, Origene), scrambled siRNA as negative control (SR30004, Origene), or dye-labeled siRNA (SR30002, Origene) for the trans;TEGRIN Β1 RAW264.7 cells were passaged and plated on Petri dishes (diameter 35 mm) with PMA. After cell culture for 40 h, integrin β2 specific siRNA (Itgb2 Mouse siRNA Oligo Duplex, SR419987, Origene), integrin β1 specific siRNA (Itgb1 Mouse siRNA Oligo Duplex, SR427527, Origene), scrambled siRNA as negative control (SR30004, Origene), or dye-labeled siRNA (SR30002, Origene) for the trans
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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