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Ctsl Mouse siRNA Oligo Duplex (Locus ID 13039)

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SKU
SR411229
Ctsl (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "Ctsl or NM_009984"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
Ctsl (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 13039)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_009984
UniProt ID P06797
Synonyms 1190035F06Rik; CatL; Ctsl1; fs; ME; MEP; nkt
Summary This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to bacterial infection. A pseudogene of this gene has been identified in the genome. provided by RefSeq, Aug 2015
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1
Park, Son, Kim et al
Nat Commun (2025) 16 (1), 10706 DOI: 10.1038/s41467-025-64500-0
Cited by 8
AI Summary: OriGene’s siRNAs targeting Ctsl (SR411229) and Bnip3 (SR404627) were used to knock down these genes in C2C12 myotubes, enabling the study to investigate their roles in muscle wasting and tumor progression during anti-PD-L1 therapy.
Snippet: ollowing differentiation, C2C12 myotubes were transfected with 20 nM of siRNAs against Ctsl (SR411229, OriGene Technologies, Rockville, MD, USA) or Bnip3 (SR404627, OriGene Technologies) using Lipofectamine RNAiMax (13778150, Invitrogen) for 24 h. Then, C2C12 myotubes were co-cultured with splenic CD8+ T cells in the presence of either DM or CM for an additional 72 h
FigureFigureFigure
Showing 1-1 of 1 papers.
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