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ULK1 Human siRNA Oligo Duplex (Locus ID 8408)

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SKU
SR322391
ULK1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  • SR322391 is the updated version of SR305509.
  $518.00
In Stock*

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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "ULK1 or NM_003565"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
ULK1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 8408)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_003565
UniProt ID O75385
Synonyms ATG1; ATG1A; hATG1; UNC51; Unc51.1
Summary Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).UniProtKB/Swiss-Prot Function
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
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file-alt Citations

Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology
Pan, Wang, Zhang et al
Nat Aging (2026) 6 (5), 1079-1102 DOI: 10.1038/s43587-026-01108-z
Cited by 14
AI Summary: OriGene products, specifically siRNAs targeting ULK1 (SR322391), PINK1 (SR324912), Parkin (SR321228), FUNDC1 (SR315322), Ambra1 (SR310808), and BNIP3 (SR300461), were used to selectively knock down these genes and investigate their roles in autophagy and mitophagy pathways relevant to Alzheimer's disease pathology.
Snippet: increase transfection efficiency;the experiments were performed according to the protocol provided by the manufacturer. The siRNA reagents used including siRNA targeting ULK1 (catalog no. SR322391, OriGene), PINK1 (catalog no. SR324912, OriGene), Parkin (catalog no. SR321228, OriGene), FUNDC1 (catalog no. SR315322, OriGene), Ambra1 (catalog no. SR310808, OriGene), BNIP3 (catalog no. SR300461, Or
FigureFigureFigure
The Mitochondrial Guardian α-Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK-SARM1-ULK1 Axis
Cao, Jiménez-Loygorri, Qiu et al
Adv Sci (Weinh) (2026)
Cited by 5
AI Summary: OriGene products, specifically ULK1 (Human) – 3 unique 27mer siRNA duplexes (SR322391) and MAP3K12 (Human) – 3 unique 27mer siRNA duplexes (SR305269), were used in this study to selectively knock down target genes and investigate the molecular mechanisms by which α-Amyrin modulates the DLK-SARM1-ULK1 axis in Alzheimer's disease models.
Snippet: Film was purchased from AGFA. ULK1 (Human) – 3 unique 27mer siRNA duplexes (SR322391), MAP3K12 (Human) – 3 unique 27mer siRNA duplexes (SR305269) were purchased from OriGene. Vectashield Antifade Mounting Medium (H-1000-10) was purchased from Vector Laboratories. APPSL-GFP Alzheimer's lentiviruses and LentiBrite GFP lentiviruses were purch
NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
Fang, Hou, Lautrup et al
Nat Commun (2019) 10 (1), 5284 DOI: 10.1038/s41467-019-13172-8
AI Summary: OriGene’s WRN human siRNA oligo duplex (CAT#: SR322215) was used to generate WRN knockdown cells, enabling the study of Werner syndrome mechanisms and the effects of NAD+ augmentation in this research.
Snippet: cell lines HT01 (#AG09599) and the WS01 (#AG03141) cells were acquired from Coriell Institute. The WRN-KD cells were siRNA knockdown in HT01 cells using WRN human siRNA ologo duplex (CAT#: SR322215, Origene). … cell lines HT01 (#AG09599) and the WS01 (#AG03141) cells were acquired from Coriell Institute. The WRN-KD cells were siRNA knockdown in HT01 cells using WRN human siRNA ologo duplex (CAT#: SR322215, Origene). …
FigureFigureFigure
Showing 1-3 of 3 papers.
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