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Prdm16 (NM_027504) Mouse Tagged ORF Clone Lentiviral Particle

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MR222596L3V
Lenti ORF particles, Prdm16 (Myc-DDK-tagged) - Mouse PR domain containing 16 (Prdm16), transcript variant 1, 200ul, >10^7 TU/mL
file-pdf Biosafety Sheet
ORF Plasmid:
tGFP DDK
Lentiviral Particles:
DDK w/ Puro mGFP w/ Puro
  $1,660.00
2 Weeks*
Bulk Requests & Clone Modifications

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Other products for "Prdm16 or NM_027504"

Specifications
Specifications
Product Data
Type Mouse Tagged ORF Clone Lentiviral Particle
Tag Myc-DDK
Target Symbol Prdm16
Synonyms 5730557K01Rik; csp1; mel1
Vector pLenti-C-Myc-DDK-P2A-Puro
Mammalian Cell Selection Puromycin
Sequence Data
ORF Nucleotide Sequence
The ORF insert of this clone is exactly the same as(MR222596).
ACCN NM_027504
ORF Size 3825 bp
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Shipping Dry Ice
Reference Data
RefSeq NM_027504.3, NP_081780.3
RefSeq Size 8605 bp
RefSeq ORF 3828 bp
Locus ID 70673
UniProt ID A2A935
Cytogenetics 4 E2
Summary Binds DNA and functions as a transcriptional regulator (PubMed:18483224). Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (PubMed:22939622). Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation (PubMed:22939622). Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation (PubMed:22939622). Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism (PubMed:17618855, PubMed:18483224). Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells (PubMed:18719582, PubMed:19641492). Functions as a repressor of TGF-beta signaling.UniProtKB/Swiss-Prot Function
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Documents
Resources

file-alt Citations

PRDM16 Regulates Prostate Cancer Cell Dormancy and Prevents Bone Metastatic Outgrowth
Nasr, Wadie, Li et al
Cancer Res (2025)
Cited by 1
AI Summary: OriGene products contributed to the study by providing the Lenti ORF viral particles for PRDM16 tagged with Myc-DDK (MR222596L3V) and the pLenti-C-Myc-DDK-P2A-Puro non-targeting control (PS100092V), which were used to manipulate PRDM16 expression and investigate its role in prostate cancer cell dormancy.
Snippet: … For PRDM16 ectopic expression, we purchased Lenti ORF viral 141 particles for Prdm16 tagged with Myc-DDK (MR222596L3V, Origene), with pLenti-C-Myc142 DDK-P2A-Puro as non-targeting control (PS100092V, Origene). …We used Subcellular protein fractionation kit (78840, Thermo 145 Scientific) to check for PRDM16 cellular localization acc
Dissecting the Intrinsic and Extrinsic Regulators of Prostate Cancer Dormancy in the Bone Microenvironment
Nasr
Thesis (2025)
AI Summary: OriGene products MR222596L3V (a specific lentiviral construct) and pLenti-C-Myc-DDK-P2A-Puro (PS100092V, a non-targeting control) were used for genetic manipulation and control experiments in prostate cancer cell lines to study dormancy mechanisms in the bone microenvironment.
Snippet: (MR222596L3V, Origene), with pLenti-C-Myc-DDK-P2A-Puro as non-targeting control (PS100092V, Origene). For RM1 cells and 22Rv1, we used MOI = 5 and MOI= 1 respectively. Bulk transduction and single clones were selected, and phenotype was
Showing 1-2 of 2 papers.
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