MSH3 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a C terminal 300 amino acids of human mutS homolog 3 (E. coli) |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | mutS homolog 3 |
| Database Link | |
| Background | The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta; part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. |
| Synonyms | DUP; FAP4; MRP1 |
| Reference Data | |
| Protein Categories | Cancer: Gastrointestinal, Cancer: Gynecologic, Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
| Protein Pathways | Colorectal cancer, Mismatch repair, Pathways in cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
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Citations
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.