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Kat5 Mouse siRNA Oligo Duplex (Locus ID 81601)

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SKU
SR415850
Kat5 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
3 Weeks*

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Other products for "Kat5 or NM_001199247"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
Kat5 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 81601)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001199247, NM_001199248, NM_001199249, NM_178637, NR_037603, NM_001362370, NM_001362371, NM_001362372
UniProt ID Q8CHK4
Synonyms AI839539; CPLA2; Htatip; Htatip1; PLIP; Tip55; Tip60
Summary Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (By similarity). NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (By similarity). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity). Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer (PubMed:22539723). Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2 (By similarity). Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134' (By similarity). Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer (PubMed:22539723).UniProtKB/Swiss-Prot Function
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

KAT5 promotes invasion and metastasis through C-MYC stabilization in ATC
Wei, Cai, Boohaker et al
Endocr. Relat. Cancer (2019) 26 (1), 141-151 DOI: 10.1530/ERC-18-0193
AI Summary: OriGene’s KAT5 Trilencer-27 siRNA was used in this study to specifically knock down KAT5 expression in cellular models, enabling the authors to investigate KAT5’s role in promoting invasion and metastasis in anaplastic thyroid cancer.
Snippet: Yuet-kin Leung (University of Cincinnati College of Medicine, USA), and CalFectin (SignaGen, Ijamsville, MD, USA) was used to transfect the plasmid into cells. KAT5 Trilencer-27 siRNA was purchased from OriGene (Rockville)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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