Cd14 Mouse siRNA Oligo Duplex (Locus ID 12475)
$518.00
In Stock*
Specifications
| Product Data | |
| Purity | HPLC purified |
|---|---|
| Quality Control | Tested by ESI-MS |
| Sequences | Available with shipment |
| Components |
Cd14 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 12475)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
|
| Stability | One year from date of shipment when stored at -20°C. |
| Shipping | Ambient |
| # of Transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
| Note | Single siRNA duplex (10nmol) can be ordered. |
| Reference Data | |
| RefSeq | NM_009841 |
| UniProt ID | P10810 |
| Summary | This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. provided by RefSeq, Jul 2014 |
| Performance Guaranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Citations
LPS and IL-1 differentially activate mouse and human astrocytes: Role of CD14
Tarassishin, Suh, Lee
Glia (2014)
Tarassishin, Suh, Lee
Glia (2014)
Cited by 212
AI Summary: OriGene’s mouse CD14 27mer siRNA duplex was used in this study to specifically silence CD14 expression in mouse astrocytes, enabling the authors to demonstrate the critical role of CD14 in mediating LPS-induced astrocyte activation.
Snippet: The mouse CD14 27mer siRNA duplex was purchased from OriGene Technologies, and was transfected using the SiPORT NeoFX Transfection reagent (Life Technologies/Invitrogen) according to the manufacturer's instructions. ... Cite SaveSaving
Showing 1-1 of 1 papers.
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in shipping.
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