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Ormdl3 Mouse siRNA Oligo Duplex (Locus ID 66612)

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SKU
SR403232
Ormdl3 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

Frequently Bought Together (3)

TT320001 siTran 2.0 siRNA transfection reagent (0.5ml)
500 ul
$280.00
SR30002 Trilencer-27 Fluorescent-labeled transfection control siRNA duplex - 1 nmol
1 nmol
$142.00
TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
20 ul
$265.00

Other products for "Ormdl3 or NM_025661"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
Ormdl3 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 66612)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_025661
UniProt ID Q9CPZ6
Synonyms 2810011N17Rik; AI315223
Summary Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).UniProtKB/Swiss-Prot Function
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes
Yang, Sheng, Sun et al
Aging (Albany NY) (2019) 11 (9), 2787-2796 DOI: 10.18632/aging.101949
AI Summary: OriGene products, specifically siRNAs targeting ORMDL3 (SR403232) and ATF6 (SR418766), were used to manipulate gene expression and investigate the roles of these proteins in beta cell proliferation during early diabetes.
Snippet: Small interfering RNA (siRNA) for ORMDL3 and ATF6 were obtained from OriGene Technologies, Inc. (Catalog number: SR403232 and SR418766;Rockville, MD, USA). …
FigureFigureFigure
Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate
Miller, Tam, Mueller et al
J. Immunol. (2017)
AI Summary: In this study, OriGene's siRNA against ORMDL3 and siTran transfection reagent were used to inhibit ORMDL3 expression in airway epithelial cells, enabling the researchers to assess the impact of ORMDL3 suppression on airway responsiveness and sphingosine-1-phosphate levels.
Snippet: ORMDL3 and activation of ATF6a Tracheal airway epithelial cells were grown on six-well plates containing poly-L- lysine-treated cover slips to a confluency of 50% and transfected with siRNA against ORMDL3 (OriGene) using siTran (OriGene), according to the manufacturer's ... All 2 versions Cite SaveSaving
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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