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MAP3K19 Human siRNA Oligo Duplex (Locus ID 80122)

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SKU
SR325092
MAP3K19 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  • SR325092 is the updated version of SR312797.
  $518.00
In Stock*

Frequently Bought Together (3)

TT320001 siTran 2.0 siRNA transfection reagent (0.5ml)
500 ul
$280.00
SR30002 Trilencer-27 Fluorescent-labeled transfection control siRNA duplex - 1 nmol
1 nmol
$142.00
TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
20 ul
$265.00

Other products for "MAP3K19 or NM_001018043"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
MAP3K19 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 80122)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001018043, NM_001018044, NM_001018045, NM_001018046, NM_001018047, NM_001282883, NM_001321177, NM_025052
UniProt ID Q56UN5
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
Hoang, Nyswaner, Torres-Ayuso et al
J. Biol. Chem. (2020)
AI Summary: OriGene’s MAP3K19 and MLK1 wild-type constructs were used in this study to express these kinases in cells, enabling the authors to investigate their role in activating ERK and JNK signaling pathways and promoting the survival of KRAS-mutant lung cancer cells.
Snippet: The following day, cells were transfected with the designated amount of plasmid DNA using jetPRIME transfection reagent (Polyplus Transfection) for the indicated time points. MAP3K19 and MLK1 wild-type constructs were purchased as entry vector (OriGene)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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