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BRD4 Human siRNA Oligo Duplex (Locus ID 23476)

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SKU
SR323604
BRD4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  • SR323604 is the updated version of SR308301.
  $518.00
In Stock*

Frequently Bought Together (3)

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SR30002 Trilencer-27 Fluorescent-labeled transfection control siRNA duplex - 1 nmol
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TT300007S A non-viral, non-electroporation, non-liposomal transfection kit using engineered mammalian proteins, tailored for high-efficiency delivery into a wide range of primary cells and difficult to transfect cell lines such as immune cells, stem cells, and neuronal cells.
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Other products for "BRD4 or NM_001330384"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
BRD4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 23476)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001330384, NM_014299, NM_058243
UniProt ID O60885
Synonyms CAP; HUNK1; HUNKI; MCAP
Summary The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. provided by RefSeq, Jul 2008
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Screening of an epigenetic compound library identifies BRD4 as a potential antiviral target for hepatitis B virus covalently closed circular DNA transcription
Yu, Long, Shen et al
Antiviral Research (2023) 211, 105552 DOI: 10.1016/j.antiviral.2023.105552
Cited by 26
AI Summary: OriGene’s Human BRD4 siRNA (cat# SR323604) was used in this study to specifically knock down BRD4 expression, helping demonstrate that BRD4 depletion inhibits hepatitis B virus cccDNA transcription and supports BRD4 as a potential antiviral target.
Snippet: … Save;Human BRD4 siRNA (a pool of 3 unique 27-mer siRNA oligo duplexes) was purchased from OriGene (cat# SR323604). Control siRNA was purchased from Santa Cruz Biotechnology (cat# sc-37007). …
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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