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KEAP1 Human siRNA Oligo Duplex (Locus ID 9817)

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SKU
SR322898
KEAP1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  • SR322898 is the updated version of SR306572.
  $518.00
In Stock*

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Other products for "KEAP1 or NM_012289"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
KEAP1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 9817)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_012289, NM_203500
UniProt ID Q14145
Synonyms INrf2; KLHL19
Summary This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. provided by RefSeq, Jul 2008
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
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file-alt Citations

Polybrominated biphenyls induce liver injury by disrupting the KEAP1/Nrf2/SLC7A11 axis leading to impaired GSH synthesis and ferroptosis in hepatocytes
Jin, Zhang, Xia et al
Arch Toxicol (2025)
Cited by 9
AI Summary: OriGene’s Stealth RNAi kit (SR322898) was used to knock down Keap1 expression in THLE-2 cells, enabling the authors to demonstrate the role of the KEAP1/Nrf2/SLC7A11 axis in PBB-induced ferroptosis and liver injury.
Snippet: Keap1 was knocked down in THLE-2 cells using the Stealth RNAi kit (SR322898, Origene, China). Cells were seeded into six-well plates, cultured to approximately 80% confluence, and transfected with Lipofectamine 3000 (Invitrogen, Camarillo, CA, USA) accor
Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis
Hsu, Wang, Yao et al
Cell Death Dis (2022) 13 (12), 1060 DOI: 10.1038/s41419-022-05512-2
Cited by 63
AI Summary: In this study, OriGene’s NFE2L2 human siRNA oligo duplex and universal scrambled negative control duplex were used to specifically knock down Nrf2 expression in colorectal cancer cells, helping to demonstrate the role of Nrf2 in mediating sensitivity to L-selenocystine-induced cell death.
Snippet: WiDr and C2BBe1 cells were transfected with siRNA using Lipofectamine RNAiMAX Reagent (Invitrogen). NFE2L2 human siRNA oligo duplex and universal scrambled negative control duplex were obtained from OriGene. siGENOME human KEAP1 siRNA-smart pool and nontarget siRNA pool were purchased from Dharmacon siGENOME. The cells were transfected with siRNA against NRF2 or KEAP1 or universal scrambled nega;- NFE2L2 human siRNA oligo duplex and universal scrambled negative control duplex were obtained from OriGene. siGENOME human KEAP1 siRNA-smart pool and
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Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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