COMT Human siRNA Oligo Duplex (Locus ID 1312)
- SR319770 is the updated version of SR300927.
$518.00
In Stock*
Specifications
| Product Data | |
| Purity | HPLC purified |
|---|---|
| Quality Control | Tested by ESI-MS |
| Sequences | Available with shipment |
| Components |
COMT (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 1312)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
|
| Stability | One year from date of shipment when stored at -20°C. |
| Shipping | Ambient |
| # of Transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
| Note | Single siRNA duplex (10nmol) can be ordered. |
| Reference Data | |
| RefSeq | NM_000754, NM_001135161, NM_001135162, NM_007310, NM_001362828 |
| UniProt ID | P21964 |
| Synonyms | HEL-S-98n |
| Summary | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. provided by RefSeq, Sep 2008 |
| Performance Guaranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Citations
Suppressor effect of catechol-O-methyltransferase gene in prostate cancer
Hashimoto, Shiina, Maekawa et al
PLoS One (2021) 16 (9), e0253877 DOI: 10.1371/journal.pone.0253877
Hashimoto, Shiina, Maekawa et al
PLoS One (2021) 16 (9), e0253877 DOI: 10.1371/journal.pone.0253877
Cited by 8
AI Summary: In this study, OriGene products—specifically the COMT expression plasmid (OriGene, Cat# RC217573) and COMT shRNA (OriGene, Cat# TL312950)—were used to manipulate COMT levels in prostate cancer cell lines, enabling the authors to assess the gene's suppressive effects on cancer cell migration, proliferation, and apoptosis.
Showing 1-1 of 1 papers.
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