ALDH1L1 Human siRNA Oligo Duplex (Locus ID 10840)
$518.00
In Stock*
Specifications
| Product Data | |
| Purity | HPLC purified |
|---|---|
| Quality Control | Tested by ESI-MS |
| Sequences | Available with shipment |
| Components |
ALDH1L1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 10840)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
|
| Stability | One year from date of shipment when stored at -20°C. |
| Shipping | Ambient |
| # of Transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
| Note | Single siRNA duplex (10nmol) can be ordered. |
| Reference Data | |
| RefSeq | NM_001270364, NM_001270365, NM_012190, NM_144776, NR_072979 |
| UniProt ID | O75891 |
| Synonyms | 10-fTHF; 10-FTHFDH; FDH; FTHFD |
| Summary | The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. provided by RefSeq, Jun 2012 |
| Performance Guaranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
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Resources
Citations
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners
Sun, Lu, Liu et al
Cell Rep Med (2025)
Sun, Lu, Liu et al
Cell Rep Med (2025)
Cited by 5
AI Summary: In this study, OriGene products—including the GPX1 overexpression vector (Cat# SC119804), empty vector (Cat# PCMV6XL5), control siRNA (Cat# SR30004), UNC5CL siRNA (Cat# SR316676), and Aldh1l1 siRNA (Cat# SR307386)—were used to manipulate gene expression and investigate the molecular mechanisms by which PGK1 contributes to diabetic kidney disease.
Showing 1-1 of 1 papers.
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