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COPB2 Human siRNA Oligo Duplex (Locus ID 9276)

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SKU
SR306142
COPB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "COPB2 or NM_004766"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
COPB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 9276)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_004766, NR_023350
UniProt ID P35606
Synonyms beta'-COP; MCPH19
Summary The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.supplied by OMIM, Jul 2002
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration
Pu, Jiang, Li et al
Med. Sci. Monit. (2020) 26, e918382 DOI: 10.12659/MSM.918382
AI Summary: OriGene products, specifically the COPB2-siRNA (No. SR306142) and scrambled negative control siRNA (No. SR30004), were used to manipulate COPB2 gene expression in NCI-H1975 lung adenocarcinoma cells, enabling the study of COPB2's role in cell proliferation, migration, and its regulation by miR-335-3p.
Snippet: The scrambled negative control siRNA (NC) (No. SR30004) (5−-CCUAAGGUUAAGUCGCCCUCG-3−) and COPB2-siRNA (siCOPB2) (No. SR306142) were purchased from OriGene Technologies (Rockville, MD, USA). The;used. The scrambled negative control siRNA (NC) (No. SR30004) (5'- CCUAAGGUUAAGUCGCCCUCG-3') and COPB2-siRNA (siCOPB2) (No. SR306142) were purchased from OriGene Technologies (Rockville, MD, USA). The
COPB2 promotes cell proliferation and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma cells
Pu, Wang, Li et al
Biomed. Pharmacother. (2018) 103, 373-380 DOI: 10.1016/j.biopha.2018.04.006
AI Summary: OriGene products, including COPB2 siRNA (SR306142), YAP1 siRNA (SR323110), and empty vector controls, were used to modulate gene expression and serve as experimental controls in investigating the roles of COPB2 and YAP1 in lung adenocarcinoma cell proliferation and tumorigenesis.
Snippet: siRNA (No. SR306142) and YAP1 (No. SR323110)were purchased from OriGene (MA, USA). The empty vector obtained from OriGene (MA, USA) was used as the negative control of COPB2 and YAP1 plasmids. The cells were
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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