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STK3 Human siRNA Oligo Duplex (Locus ID 6788)

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SKU
SR304635
STK3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "STK3 or NM_001256312"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
STK3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6788)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001256312, NM_001256313, NM_006281
UniProt ID Q13188
Synonyms KRS1; MST2
Summary This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2012
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
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file-alt Citations

LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer
Nozaki, Yabuta, Fukuzawa et al
Oncotarget (2019) 10 (10), 1014-1030 DOI: 10.18632/oncotarget.26583
Snippet: he Hippo pathway, the EMT, and cell division. Hippo pathway LATS SNAIL oral cancer cancer stem cells (CSCs) INTRODUCTION Cancer stem cells (CSCs), also called tumor-initiating cells (TICs), drive tumorigenesis and tumor heterogeneity through their abilities to self-renew and generate tumorigenic progeny. These cells are also resistant to a wide range of therapeutic agents, including chemotherapy
FigureFigureFigure
Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis
Okamoto, Yabuta, Mukai et al
Cell Cycle (2015)
Cited by 15
AI Summary: In this study, OriGene's Mst2 siRNAs (catalog #SR304635) were used to specifically silence Mst2 expression, enabling the authors to investigate the role of Mst2 in the regulation of CHO1 phosphorylation and cytokinesis.
Snippet: …The following siRNA duplexes were used: firefly luciferase (GL2) as a negative control, 5’-CGUACGCGGAAUACUUCGAdTdT-3’;Lats1-3509, 5’-ACUUUGCCGAGGACCCGAAdTdT-3’;Lats2-581, 5’-GUUCGGACCUUAUCAGAAAdTdT-3’;LIMK1, 5’- UGGCAAGCGUGGACUUUCAdTdT-3’;and 3’UTR of CHO1/MKLP1 5’-GCAGUCUUCCAGGUCAUCUdTdT-3’. The Mst2 siRNAs (#1–3) were purchased from OriGene (SR304635)
Showing 1-2 of 2 papers.
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