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STAT2 Human siRNA Oligo Duplex (Locus ID 6773)

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SKU
SR304621
STAT2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "STAT2 or NM_005419"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
STAT2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6773)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_005419, NM_198332
UniProt ID P52630
Synonyms IMD44; ISGF-3; P113; PTORCH3; STAT113
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. provided by RefSeq, Aug 2020
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection
Kwock, Handfield, Suwanpradid et al
Sci Adv (2020) 6 (14), eaay3245 DOI: 10.1126/sciadv.aay3245
Cited by 56
AI Summary: OriGene products, specifically siRNA transfection buffer and transfection reagent, were used to facilitate the delivery of siRNA constructs into cells for gene knockdown experiments in this study.
Snippet: siRNA constructs were obtained from either Dharmacon or OriGene. siRNA transfection buffer and transfection reagent were obtained from OriGene. Cells were plated 1 day before transfection, and medium was changed to serum-free medium 2 hours before transfection. siRNA constructs were resuspended in 1× transfection buffer at a concentration of 0.02 nmol/μl. Each construct (1.7 μl) was added to a 200...
FigureFigureFigure
Showing 1-1 of 1 papers.
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