IKB beta (NFKBIB) Human siRNA Oligo Duplex (Locus ID 4793)
$518.00
In Stock*
Specifications
| Product Data | |
| Purity | HPLC purified |
|---|---|
| Quality Control | Tested by ESI-MS |
| Sequences | Available with shipment |
| Components |
NFKBIB (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 4793)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
|
| Stability | One year from date of shipment when stored at -20°C. |
| Shipping | Ambient |
| # of Transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
| Note | Single siRNA duplex (10nmol) can be ordered. |
| Reference Data | |
| RefSeq | NM_001001716, NM_001243116, NM_002503, NR_040515, NM_001369699, NM_001369700, NR_161470 |
| UniProt ID | Q15653 |
| Synonyms | IKBB; TRIP9 |
| Summary | The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.provided by RefSeq, Jul 2011 |
| Performance Guaranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Reviews
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Resources
Citations
Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk
Lin, Ge, Wang et al
Sci Rep (2017) 7, 42498 DOI: 10.1038/srep42498
Lin, Ge, Wang et al
Sci Rep (2017) 7, 42498 DOI: 10.1038/srep42498
AI Summary: OriGene contributed pCMV6 vectors for IκBβ and wild-type/mutant lnc-MKI67IP-3, which were used to investigate the molecular mechanisms by which let-7e regulates inflammation in vascular endothelial cells.
Snippet: conditions. Cells of the same batch were used in all experiments. SiRNA and pCMV6 vectors of IκBβ and wide/mutant lnc-MKI67IP-3 were obtained from GenePharma (Shanghai, China) or Origene (Rockville, USA). The mimic ... All 3 versions Cite SaveSaving
Showing 1-1 of 1 papers.
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