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CDA Human siRNA Oligo Duplex (Locus ID 978)

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SKU
SR300700
CDA (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
  $518.00
In Stock*

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Other products for "CDA or NM_001785"

Specifications
Specifications
Product Data
Purity HPLC purified
Quality Control Tested by ESI-MS
Sequences Available with shipment
Components
CDA (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 978)
Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmol
Included - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml
Stability One year from date of shipment when stored at -20°C.
Shipping Ambient
# of Transfections Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM).
Note Single siRNA duplex (10nmol) can be ordered.
Reference Data
RefSeq NM_001785
UniProt ID P32320
Synonyms CDD
Summary This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. provided by RefSeq, Jul 2008
Performance Guaranteed OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency.

For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required).
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Documents
Resources

file-alt Citations

Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5'-deoxy-5-fluorocytidine (5'-DFCR)
Gao, Zens, Su et al
J Exp Clin Cancer Res (2021) 40 (1), 138 DOI: 10.1186/s13046-021-01938-2
Cited by 19
AI Summary: OriGene’s CDA Human siRNA Oligo Duplex (Locus ID 978) was used in this study to specifically knock down CDA gene expression, enabling the authors to investigate the role of CDA in chemotherapy resistance and sensitivity to 5'-DFCR in non-small cell lung cancer cells.
Snippet: Infinite M1000. siRNA-based gene expression silencing siRNA-based knockdown of CDA mRNA expression (siCDA) was achieved by 3 unique 27mer siRNA duplexes (CDA Human siRNA Oligo Duplex [Locus ID 978], OriGene). Transfection of siRNAs was performed with Lipofectamine 2000 according to the manufacturer’s instructions. Clonogenic assay A549 holoclone and paraclone cells, as also parental A549 cells
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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